Using nano-diamond technology, this novel scientific research has solved the thorny problem of tumor cells excreting therapeutic drugs out of cells, especially in the process of chemotherapy, the diseased cells will be resistant, and this problem has always caused headaches for doctors.
The research results were published in Nanomedicine: Nanotechnology, Biology, and Medicine. Hosted by Edward Chow, Principal Investigator of the Singapore Cancer Institute and Professor Dean Ho of the University of California.
Problem: Leukemia disease cell resistance
Daunorubicin (daunorubicin) is a common drug for the treatment of leukemia. It treats the disease by delaying and preventing the growth of tumor cells, and eventually kills the diseased cells. However, tumor cells that are diseased during treatment are prone to resistance to daunorubicin.
The pathology of leukemia resistance is the process by which the therapeutic drug is excreted by the diseased cells during the course of chemotherapy, and of course the drug resistance process of daunorubicin is rejected by the tumor cells.
Interventional therapy for nanodiamond
At present, most of the ways to solve drug resistance in the medical community are to develop antibodies, but this method is often hampered by the toxicity and effectiveness of the drugs in clinical trials.
In view of this, researchers of NUS and UCLA began to break through the idea and turned the hope of treatment to nanodiamonds with a diameter of only 2-8 nm.
The researchers immobilized daunorubicin on the surface of the nanodiamond and then interposed the diamond-daunorubicin mixture into the diseased cells. The study found that nanodiamond can smoothly bring daunorubicin into the cell, instead of being discharged by cells as before, thus solving the problem of drug resistance of diseased cells. Due to the non-invasive size and unique surface characteristics of nanodiamonds, diamond particles can be easily released into blood vessels without clogging the blood vessels.
Dr. Chow said: "The intervention of nanodiamonds greatly enhances the combination of biocompatibility and tolerance, and thereby enhances the efficacy; currently, in vivo and in vitro drug safety test results initially show that the drug is affected The drug is better, which laid a good foundation for further research in the next step."
Professor Dean Ho added: Nanodiamond is a therapeutic carrier with great medical research prospects. At present, we need to further determine which drugs nano-diamond can carry to treat specific diseases, so as to maximize the well-being of patients.
For further research, the team decided to conduct a safety assessment of this nanodiamond hybrid drug and began to enter clinical trials. Researchers hope that their results will translate from laboratory testing to clinical treatment, which will result in substantial treatment for leukemia. At the same time, the team also hopes to find a breakthrough in the combination of nanodiamonds and other drugs to treat other diseases. (Compiled from "Tiny diamonds to boost treatment of chemoresistant leukemia")
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